large b cell lymphoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T16040	Mepazine	Pecazine	Apoptosis , MALT
	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.		Apoptosis , MALT
T9203	JH-X-119-01		IRAK
	JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.		IRAK
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T3549	Avadomide	CC 122	Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.		Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
T77367	Urelumab	BMS-663513,BMS-66513	Others
	Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the...		Others
T77135	Tafasitamab	MOR00208,XmAb5574,Tafasitamab-cxix	Apoptosis , Immunology/Inflammation related
	Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.		Apoptosis , Immunology/Inflammation related
T12186	Navitoclax-piperazine	ABT-263-piperazine	BCL , Ligands for Target Protein for PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).		BCL , Ligands for Target Protein for PROTAC
T60008	BCL6-IN-6		BCL
	BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.		BCL
T9969	EZM0414		Histone Methyltransferase
	EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay. EZM0414 can be used for the research of relapsed or refractory m...		Histone Methyltransferase
T25400	EZH2-IN-3	EZH2 inhibitor 3,EZH2-inhibitor-3
	EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.
T61767	IRAK4-IN-17
	IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].
T76946	Zuberitamab
	Zuberitamab (HS006) is a monoclonal antibody targeting CD20, utilized in cancer research, notably in diffuse large B-cell lymphoma [1].
T73869	BCL6 PROTAC 1
	BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph...
T77070	Loncastuximab
	Loncastuximab (RB4v1.2), an anti-CD19 monoclonal antibody, exhibits antitumor properties and holds potential for treating non-Hodgkin's lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL) [1] [2].
T77940	Tazemetostat de(methyl morpholine)-COOH		Ligands for Target Protein for PROTAC
	Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse la...		Ligands for Target Protein for PROTAC
T62403	DM-01
	DM-01 is a potent and selective inhibitor of EZH2. DM-01 can be used to study diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and SNF5/INI-1/SMARCB1 gene-associated solid tumours.
T40901	Aderbasib	INCB007839,INCB7839
	Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for...
T81696	NBI-961
	NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell lymphoma (DLBCL) cells [1].